Rose Men: Luke and Owen Wilson star in a buddy comedy about two landscapers who vie for Kate Hudson's love. She employs them. Somebody falls in poop.
I Rub You 2: Owen Wilson is an Arabian Genie Luke Wilson finds. He wishes for Kate Hudson. Gene Hackman plays Jafar in this coming of age buddy film.
Shoestore Cowboys: Luke and Owen Wilson, ranchers, inherit a high end shoe store from their dying uncle Gene Hackman. Coming of age buddy comedy.
In Traction: Luke and Owen Wilson play wisecracking young doctors. Gene Hackman plays evil patient. Zach Braff costars. Coming of age comedy.
Wedding Wing: Luke Wilson marries a falcon. Owen Wilson is its stern trainer. It's a coming of age buddy comedy.
God is My Co-Pirate: Luke Wilson's plane is hijacked by Muslim terrorist Owen Wilson. They were college roommates, so it's a buddy comedy.
Great Balls of Fire: Luke and Owen Wilson play young balls of fire. They have to defeat Gene Hackman, water. Coming of age film/buddy comedy.
Twilight - Wilson Moon: Werewolves Luke and Owen Wilson vie for Bella's love in this buddy comedy by Wes Craven. Gene Hackman plays Edward.
Tragedy at AIDS Lake: Luke and Owen Wilson star in this buddy comedy about falling in water with your clothes on. Gene Hackman keeps pushing them.
Also, from my human associate (barely human - seems more like a asteroid snake in disguise. *Remember to check into that later*), Jeff Robtoy:
College Dayz: Luke and Owen Wilson make big cash as local cover band 'Sublime' in a college town. Gene Hackman as the evil FCC CEO who tries to ruin the fun!
The Royal Tennenbaums: Luke and Owen Wilson are pretentious actors who join a neo-nazi movement to score tail. Gene Hackman as Mr. Tennenbaum. Danny Glover hates cabs.